MersV1, France, Analysis, bibRecord, 000342

Triple-helices targeted to the polypurine tract of a murine retrovirus

Identifieur interne : 000342 ( France/Analysis ); précédent : 000341; suivant : 000343

Triple-helices targeted to the polypurine tract of a murine retrovirus

Auteurs : H. Porumb [France] ; C. Dagneaux [France] ; R. Letellier [France] ; C. Malvy ; E. Taillandier [France]

Source :

Gene [ 0378-1119 ] ; 1994.

RBID : ISTEX:F60E64195BD202D0B1ED4F9BD30BA86056448ADC

English descriptors

Teeft :
- Antiparallel, Antisense, Average counts, Bobigny cedex, Contiguous guanines, Dunni, Dunni cells, Duplex, Elution temperature, First attempt, First part, Focus immunoassay, Friend murine leukemia virus, Friend retrovirus, Ftir, Ftir spectroscopy, Guanine, Helix, Hoogsteen, Hoogsteen scheme, Individual counts, Large block, Liquier, Modeling, Molecular modeling, Murine, Murine retroviruses, Nucleic, Nucleic acids, Oligo, Oligonucleotides, Oligos, Polypurine, Polypurine tract, Porumb, Purine strand, Retrovirus, Same target, Strand, Third strand, Third strands, Transcription elongation, Triple, Triple helices, Triple helix, Triplet, Triplex, Viral foci.

Abstract

Abstract: The all-purine 13-mer oligodeoxyribonucleotide d(GGGGGGAAAAAGA), containing an unusually large block of contiguous guanines, was shown by electrophoresis and thermoelution to form a specific, ‘antiparallel’ complex with the duplex containing the polypurine tract of murine retro viruses. Fourier transform infra-red spectroscopy (FTIR) and molecular modeling indicated that the complex is based on reverse Hoogsteen G(GC) and A(AT) triplets, with anti orientations of the bases and with all the strands having S-type sugar conformations. This G + A-containing 13-mer and a G + T-containing 22-mer, d(TGTTTGTTTGGGGGGTTTTTGT), aimed at the same target, retarded in a sequence-specific manner the spreading of the Friend retrovirus in Dunni cells infected de novo, thus indicating that the polypurine tract of retroviruses may be a suitable target for anti-gene action.

Url:

https://api.istex.fr/ark:/67375/6H6-CV5RGP05-K/fulltext.pdf

DOI: 10.1016/0378-1119(94)90417-0

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000930
to stream Istex, to step Curation: 000930
to stream Istex, to step Checkpoint: 001942
to stream Main, to step Merge: 004368
to stream Main, to step Curation: 004305
to stream Main, to step Exploration: 004305
to stream France, to step Extraction: 000342

Links to Exploration step

ISTEX:F60E64195BD202D0B1ED4F9BD30BA86056448ADC

Le document en format XML

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</author>
<author><name sortKey="Dagneaux, C" sort="Dagneaux, C" uniqKey="Dagneaux C" first="C." last="Dagneaux">C. Dagneaux</name>
</author>
<author><name sortKey="Letellier, R" sort="Letellier, R" uniqKey="Letellier R" first="R." last="Letellier">R. Letellier</name>
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<author><name sortKey="Malvy, C" sort="Malvy, C" uniqKey="Malvy C" first="C." last="Malvy">C. Malvy</name>
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<author><name sortKey="Taillandier, E" sort="Taillandier, E" uniqKey="Taillandier E" first="E." last="Taillandier">E. Taillandier</name>
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<term>Antisense</term>
<term>Average counts</term>
<term>Bobigny cedex</term>
<term>Contiguous guanines</term>
<term>Dunni</term>
<term>Dunni cells</term>
<term>Duplex</term>
<term>Elution temperature</term>
<term>First attempt</term>
<term>First part</term>
<term>Focus immunoassay</term>
<term>Friend murine leukemia virus</term>
<term>Friend retrovirus</term>
<term>Ftir</term>
<term>Ftir spectroscopy</term>
<term>Guanine</term>
<term>Helix</term>
<term>Hoogsteen</term>
<term>Hoogsteen scheme</term>
<term>Individual counts</term>
<term>Large block</term>
<term>Liquier</term>
<term>Modeling</term>
<term>Molecular modeling</term>
<term>Murine</term>
<term>Murine retroviruses</term>
<term>Nucleic</term>
<term>Nucleic acids</term>
<term>Oligo</term>
<term>Oligonucleotides</term>
<term>Oligos</term>
<term>Polypurine</term>
<term>Polypurine tract</term>
<term>Porumb</term>
<term>Purine strand</term>
<term>Retrovirus</term>
<term>Same target</term>
<term>Strand</term>
<term>Third strand</term>
<term>Third strands</term>
<term>Transcription elongation</term>
<term>Triple</term>
<term>Triple helices</term>
<term>Triple helix</term>
<term>Triplet</term>
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<front><div type="abstract" xml:lang="en">Abstract: The all-purine 13-mer oligodeoxyribonucleotide d(GGGGGGAAAAAGA), containing an unusually large block of contiguous guanines, was shown by electrophoresis and thermoelution to form a specific, ‘antiparallel’ complex with the duplex containing the polypurine tract of murine retro viruses. Fourier transform infra-red spectroscopy (FTIR) and molecular modeling indicated that the complex is based on reverse Hoogsteen G(GC) and A(AT) triplets, with anti orientations of the bases and with all the strands having S-type sugar conformations. This G + A-containing 13-mer and a G + T-containing 22-mer, d(TGTTTGTTTGGGGGGTTTTTGT), aimed at the same target, retarded in a sequence-specific manner the spreading of the Friend retrovirus in Dunni cells infected de novo, thus indicating that the polypurine tract of retroviruses may be a suitable target for anti-gene action.</div>
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Triple-helices targeted to the polypurine tract of a murine retrovirus

Triple-helices targeted to the polypurine tract of a murine retrovirus

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri